This is getting out of control. (photos via ZookeeperRachel)
THE LAST ONE LOL
Watched Daredevil, courtesy of a friend. Broadly speaking I enjoyed it. I watched it to the end of the season, anyhow.
However, if sense8 went for stereotypes, Dear Goddess, could Daredevil have got anymore hopeless on that front? And oh look, they killed off or disposed of *EVERY* non-white actor by the end of the season.
So ebay, for some reason, conflates ‘Steal’ – the 1995 film with Alfred Molina, with ‘The Steal’, a 2002 film. Due to a moment of idiotdom I ended up with the latter not the former. I’d be more annoyed, but I paid £1.99 for it, so I don’t really find it in my heart to care that much.
It’d been ripped to the media server and has sat for a few weeks waiting for me to be bored enough to watch it. The awesome headache I’ve got right now was enough of a push, so I sat down and watched it. And y’know what? It’s fucking terrible.
It’s got a couple of nice action-y set pieces, and I quite like the premise, but the acting is worse even than I could do and the script… Well, the script makes the fantastic film I wrote and filmed in secondary school look like a oscar worthy piece of genius. I can’t say that I paid it a great deal of attention, it distracted from my headache sufficiently to make it worth the experience, just. But for once in my life I’m actually tempted to delete it from the media server to reclaim the space.
I was wondering why none of the black writers on OITNB called out the whites for having Taystee basically tell another black inmate to stop pulling the race card and then I remembered that the show has no black writers, and that the one POC writer on the staff, a Latino man, left after the first season. How can you make a show about the experiences of women of color in prison and have no women of color (or people of color at all) writing for your show?
In a stunning discovery that overturns decades of textbook teaching, researchers at the University of Virginia School of Medicine have determined that the brain is directly connected to the immune system by vessels previously thought not to exist.
That such vessels could have escaped detection when the lymphatic system has been so thoroughly mapped throughout the body is surprising on its own, but the true significance of the discovery lies in the effects it could have on the study and treatment of neurological diseases ranging from autism to Alzheimer’s disease to multiple sclerosis.
“Instead of asking, ‘How do we study the immune response of the brain?,’ ‘Why do multiple sclerosis patients have the immune attacks?,’ now we can approach this mechanistically – because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,” said Jonathan Kipnis, a professor in U.Va.’s Department of Neuroscience and director of U.Va.’s Center for Brain Immunology and Glia. “It changes entirely the way we perceive the neuro-immune interaction. We always perceived it before as something esoteric that can’t be studied. But now we can ask mechanistic questions.“
He added, “We believe that for every neurological disease that has an immune component to it, these vessels may play a major role. [It’s] hard to imagine that these vessels would not be involved in a [neurological] disease with an immune component.”
Kevin Lee, who chairs the Department of Neuroscience, described his reaction to the discovery by Kipnis’ lab: “The first time these guys showed me the basic result, I just said one sentence: ‘They’ll have to change the textbooks.’ There has never been a lymphatic system for the central nervous system, and it was very clear from that first singular observation – and they’ve done many studies since then to bolster the finding – that it will fundamentally change the way people look at the central nervous system’s relationship with the immune system.”
Even Kipnis was skeptical initially. “I really did not believe there are structures in the body that we are not aware of. I thought the body was mapped,” he said. “I thought that these discoveries ended somewhere around the middle of the last century. But apparently they have not.”
The discovery was made possible by the work of Antoine Louveau, a postdoctoral fellow in Kipnis’ lab. The vessels were detected after Louveau developed a method to mount a mouse’s meninges – the membranes covering the brain – on a single slide so that they could be examined as a whole. “It was fairly easy, actually,” he said. “There was one trick: We fixed the meninges within the skullcap, so that the tissue is secured in its physiological condition, and then we dissected it. If we had done it the other way around, it wouldn’t have worked.”
After noticing vessel-like patterns in the distribution of immune cells on his slides, he tested for lymphatic vessels and there they were. The impossible existed.
The soft-spoken Louveau recalled the moment: “I called Jony [Kipnis] to the microscope and I said, ‘I think we have something.’”
As to how the brain’s lymphatic vessels managed to escape notice all this time, Kipnis described them as “very well hidden” and noted that they follow a major blood vessel down into the sinuses, an area difficult to image. “It’s so close to the blood vessel, you just miss it,” he said. “If you don’t know what you’re after, you just miss it.
“Live imaging of these vessels was crucial to demonstrate their function, and it would not be possible without collaboration with Tajie Harris,” Kipnis noted. Harris is an assistant professor of neuroscience and a member of the Center for Brain Immunology and Glia. Kipnis also saluted the “phenomenal” surgical skills of Igor Smirnov, a research associate in the Kipnis lab whose work was critical to the imaging success of the study.
The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both about the workings of the brain and the diseases that plague it.
For example, take Alzheimer’s disease. “In Alzheimer’s, there are accumulations of big protein chunks in the brain,” Kipnis said. “We think they may be accumulating in the brain because they’re not being efficiently removed by these vessels.” He noted that the vessels look different with age, so the role they play in aging is another avenue to explore.
And there’s an enormous array of other neurological diseases, from autism to multiple sclerosis, that must be reconsidered in light of the presence of something science insisted did not exist.
The lymphatic system map: old (left) and new.
This is really big. This is really big news in medicine and I suspect in mental health as well. Consider the recent discoveries around the association between mental health and the immune system;
- In 2013 they confirmed Narcolepsy is an immune disorder.
- People with Post Traumatic Stress Disorder are shown to have a hyperactive immune system.
- P.A.N.D.A.S. is a recent term for a disorder used to describe the mental changes in children after Strep/Staph Infection.
There are still so many things we are finding out about the nature of disease and the human body – especially the brain.
Interestingly this agrees with what a lot of non western medical modalities have said for centuries, big stuff
Wow. I might just go chuck my A+P book in the bin, I think I need a new one.
Trying to make a point to my father.
When you read lesbian baby-making blogs online, you notice something odd. A lot of them just end. They peter our, no explanation. “We’re trying again!” they announce, and then they’re gone. Just not updated anymore.
And you know why. Because people started those blogs with a dream, and then the dream is shattered, and the blog stops. So I’m kinda glad this isn’t a baby making blog, because at least for the time being it’d be over.
We found out yesterday that we’re not eligible for the egg-sharing IVF programme, for a variety of reasons. That puts IVF firmly out of our grasp thanks to the local NHS’s delightfully discriminatory ‘you must try 10 times before we give you a go free’ policy (which for heterosexual couples just means ten months of sex, but for us means somewhere around £14,000 spending money, whilst at the same time potentially losing income due to having to be off work.). We also don’t really have the cash to throw at another 10-15% probability IUI cycle. We could, possibly, scrape it together, but the stress involved would probably lower the chances of it working fairly dramatically.
And so, the baby update is that we don’t have one. And have no idea where to go from here on that front. We’ve seen what adopting older kids is like, and beyond the fact that we want to raise a child from baby-ness, we also both agree we could not do what our friends have done. They are awesome, and their kids are awesome too, but the whole thing has been and is very challenging for them – and I don’t… we don’t want that experience.
Which leaves us here.